Abstract
Varenicline tartrate (Chantix; Pfizer), an α4β2 nicotinic receptor partial agonist, was approved by the US FDA as an aid to smoking cessation treatment in May 2006.
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References
Ezzati, M. et al. Estimates of global mortality attributable to smoking in 2000. Lancet 362, 847–852 (2003).
Henningfield, J. E. et al. Pharmacotherapy for nicotine dependence. CA Cancer J. Clin. 55, 281–299 (2005).
Dani, J. A. & Heinemann, S. Molecular and cellular aspects of nicotine abuse. Neuron 16, 905–908 (1996).
Picciotto, M. R. et al. Acetylcholine receptors containing the β2 subunit are involved in the reinforcing properties of nicotine. Nature 391, 173–177 (1998).
Tapper, A. R. et al. Nicotine activation of α4* receptors: sufficient for reward, tolerance, and sensitization. Science 306, 1029–1032 (2004).
Coe, J. W. et al. Varenicline: an α4β2 nicotinic receptor partial agonist for smoking cessation. J. Med. Chem. 48, 3474–3477 (2005).
FDA labelling information, [online] (2006).
Piper, M. E. et al. A multiple motives approach to tobacco dependence: the Wisconsin Inventory of Smoking Dependence Motives (WISDM-68). J. Consult. Clin. Psychol. 72, 139–154 (2004).
Lancaster, T. et al. Prevention of relapse after quitting smoking: a systematic review of trials. Arch. Intern. Med. 166, 828–835 (2006).
Grant, B. F. et al. Nicotine dependence and psychiatric disorders in the United States: results from the national epidemiologic survey on alcohol and related conditions. Arch. Gen. Psychiatry 61, 1107–1115 (2004).
Mackay, J. & Eriksen, M. The Tobacco Atlas. World Health Organization, [online] (2004).
IMS Health, IMS MIDAS Quantum (Dec 2005).
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Niaura, R., Jones, C. & Kirkpatrick, P. Varenicline. Nat Rev Drug Discov 5, 537–538 (2006). https://doi.org/10.1038/nrd2088
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DOI: https://doi.org/10.1038/nrd2088
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