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Cancer

A new target in Burkitt's lymphoma

Nature Reviews Drug Discovery volume 11, page 750 (2012)Cite this article

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This study identified a new pathway involved in the pathogenesis of Burkitt's lymphoma that is amenable to therapeutic targeting. Using RNA sequencing of patient biopsy samples and Burkitt's lymphoma cell lines, together with re-analysis of published sequence data, the authors identified recurrent mutations in the transcription factor TCF3 and its negative regulator ID3. TCF3 activated the pro-survival phosphatidylinositol 3-kinase pathway in Burkitt's lymphoma cells, in part by augmenting tonic B cell receptor signalling. Inhibitors of the TCF3 pathway inhibited growth of Burkitt's lymphoma cells and tumour xenografts.

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ORIGINAL RESEARCH PAPER

  1. Schmitz, R. et al. Burkitt lymphoma pathogenesis and therapeutic targets from structural and functional genomics. Nature 12 Aug 2012 (doi:10.1038/nature11378)

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Authors
  1. Charlotte Harrison
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Harrison, C. A new target in Burkitt's lymphoma. Nat Rev Drug Discov 11, 750 (2012). https://doi.org/10.1038/nrd3860

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