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Cardiovascular disease

Inhibiting microRNA-34 benefits heart disease

Nature Reviews Drug Discovery volume 11, page 908 (2012)Cite this article

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MicroRNA-34 (miR-34) family members are upregulated in the heart in response to stress. This study investigated the effects of miR-34 inhibition using a subcutaneously delivered seed-targeting 8-mer locked nucleic acid-modified antimiR (LNA-antimiR-34) in mouse models of heart disease. LNA-antimiR-34 attenuated cardiac remodelling and atrial enlargement and improved systolic function. Moreover, this study suggests that seed-targeting 8-mer LNA-antimiRs could be used to inhibit other miRNA seed families implicated in disease.

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ORIGINAL RESEARCH PAPER

  1. Bernardo, B. C. et al. Therapeutic inhibition of the miR-34 family attenuates pathological cardiac remodeling and improves heart function. Proc. Natl Acad. Sci. USA 109, 17615–17620 (2012)

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  1. Charlotte Harrison
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Harrison, C. Inhibiting microRNA-34 benefits heart disease. Nat Rev Drug Discov 11, 908 (2012). https://doi.org/10.1038/nrd3903

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