Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • In Brief
  • Published:

Immune regulation

Disassembling antibody–receptor complexes

Nature Reviews Drug Discovery volume 11, page 908 (2012)Cite this article

Subjects

Access through your institution
Buy or subscribe

Preformed complexes between immunoglobulin E (IgE) antibodies and the IgE Fcɛ receptor I (FcɛRI) prime cells before allergen exposure to trigger an inflammatory response, and cannot be disrupted by current competitive inhibitors. This study showed that an engineered protein inhibitor, DARPin E2-79, acts through a novel mechanism to stimulate the dissociation of preformed IgE–FcɛRI complexes (as well as blocking IgE–FcɛRI interactions). Such inhibitors could be used to block the allergic response, and this work suggests that other protein–protein complexes may be amenable to disruption by macromolecular inhibitors.

This is a preview of subscription content, access via your institution

Access options

Access through your institution

Buy this article

  • Purchase on SpringerLink
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

ORIGINAL RESEARCH PAPER

  1. Kim, B. et al. Accelerated disassembly of IgE–receptor complexes by a disruptive macromolecular inhibitor. Nature 28 Oct 2012 (doi:10.1038/nature11546)

    Article  CAS  Google Scholar 

Download references

Authors
  1. Charlotte Harrison
    View author publications

    Search author on:PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Harrison, C. Disassembling antibody–receptor complexes. Nat Rev Drug Discov 11, 908 (2012). https://doi.org/10.1038/nrd3904

Download citation

  • Published:

  • Issue date:

  • DOI: https://doi.org/10.1038/nrd3904

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing