Table 1 Drugs with large revenue losses in 2011–2012

From: Patent watch

Drug; company

Indications

US generic entry

2010 US sales (US$ million)

2011 US sales (US$ million)

2012 to Q3* US sales (US$ million)

Plavix (clopidogrel); Sanofi

Prevention of cardiovascular events

May 2012

6,154

6,622

2,435

Lipitor (atorvastatin); Pfizer

Dyslipidaemia

November 2011

5,329

5,003

871

Seroquel (quetiapine); AstraZeneca

Schizophrenia and bipolar disorder

March 2012

3,747

4,123

1,311

Actos (pioglitazone); Takeda

Type 2 diabetes

August 2012

3,518

3,553

1,522

Singulair (montelukast); Merck

Asthma

August 2012

3,219

3,537

2,127

Zyprexa (olanzapine); Eli Lilly

Schizophrenia and bipolar disorder

October 2011

2,495

2,165

300

Lexapro (escitalopram); Forest

Depression and anxiety

Febuary 2012

2,277

2,369

355

TriCor (fenofibrate); Abbott

Dyslipidaemia

November 2012

1,355

1,372

896

Levaquin (levofloxacin); Johnson & Johnson

Bacterial infection

June 2011

1,285

585

35

Provigil/Sparlon (modafinil); Teva

Sleep disorders, ADHD

March 2012

1,124

1,159

392

*Indicates the sales in the 9-month period to the end of September 2012. Indicates worldwide sales. ADHD, attention deficit hyperactivity disorder. Data provided by Sagient Research Systems.