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Anticancer drugs

Decoy receptor prevents metastasis

Nature Reviews Drug Discovery volume 13, page 812 (2014)Cite this article

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AXL receptor tyrosine kinase signalling drives metastasis and disease progression in a number of human cancers, representing a promising oncology target. However, attempts to therapeutically target the AXL receptor have been limited by modest antitumour efficacy and substantial off-target effects. Now, Kariolis et al. have engineered an AXL decoy receptor, MYD1 Fc, which binds the AXL ligand GAS6 with high affinity, efficiently reducing GAS6-mediated AXL phosphorylation and downstream signalling. In mouse models of advanced ovarian and breast cancer, MYD1 Fc potently inhibited metastasis and disease progression, an effect which correlated with GAS6 affinity.

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References

  1. Kariolis, M. S. et al. An engineered Axl 'decoy receptor' effectively silences the Gas6-Axl signaling axis. Nat. Chem. Biol. http://dx.doi.org/10.1038/nchembio.1636 (2014)

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  1. Sarah Crunkhorn
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Crunkhorn, S. Decoy receptor prevents metastasis. Nat Rev Drug Discov 13, 812 (2014). https://doi.org/10.1038/nrd4463

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