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Diabetes

Genetic risk factors in type 2 diabetes mellitus

Nature Reviews Endocrinology volume 5, page 414 (2009)Cite this article

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Cornelis, M. C. et al. Joint effects of common genetic variants on the risk for type 2 diabetes in U.S. men and women of European ancestry. Ann. Intern. Med. 150, 541–550 (2009).

New research has examined the discriminatory value of a genetic risk score, which includes several alleles linked to type 2 diabetes mellitus. “When combining variants into a single genetic score we observed that each additional risk variant was associated with an approximately 16% to 19% increased risk of type 2 diabetes,” describes Marilyn Cornelis from the Harvard School of Public Health. Furthermore, combining this score with conventional risk factors can identify people with a particularly high risk for type 2 diabetes mellitus.

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  1. Lisa Richards
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Richards, L. Genetic risk factors in type 2 diabetes mellitus. Nat Rev Endocrinol 5, 414 (2009). https://doi.org/10.1038/nrendo.2009.117

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