Despite advances in treating HIV infection, dyslipidemia and accelerated cardiovascular disease are prevalent in this patient population. In the Heart Positive study, Balasubramanyam et al. suggest that fenofibrate and niacin combined with diet and exercise are an effective treatment for dyslipidemia in HIV-infected patients.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$189.00 per year
only $15.75 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to the full article PDF.
USD 39.95
Prices may be subject to local taxes which are calculated during checkout
References
Grinspoon, S. & Carr, A. Cardiovascular risk and body-fat abnormalities in HIV-infected adults. N. Engl. J. Med. 352, 48–62 (2005).
Silverberg, M. J. et al. Response to newly prescribed lipid-lowering therapy in patients with and without HIV infection. Ann. Intern. Med. 150, 301–313 (2009).
Dubé, M. P. et al. Guidelines for the evaluation and management of dyslipidemia in human immunodeficiency virus (HIV)-infected adults receiving antiretroviral therapy: recommendations of the HIV Medical Association of the Infectious Disease Society of America and the Adult AIDS Clinical Trials Group. Clin. Infect. Dis. 37, 613–627 (2003).
Balasubramanyam, A. et al. Combination of niacin and fenofibrate with lifestyle changes improves dyslipidemia and hypoadiponectinemia in HIV patients on antiretroviral therapy: results of “Heart Positive,” a randomized, controlled trial. J. Clin. Endocrinol. Metab. doi:10.1210/jc.2010-3067.
Triant, V. A., Lee, H., Hadigan, C. & Grinspoon, S. K. Increased acute myocardial infarction rates and cardiovascular risk factors among patients with human immunodeficiency virus disease. J. Clin. Endocrinol. Metab. 92, 2506–2512 (2007).
U. S. Department of Health and Human Services. NIH stops clinical trial on combination cholesterol treatment. NIH News [online], (2011).
Di Angelantonio, E. et al. Major lipids, apolipoproteins, and risk of vascular disease. JAMA 302, 1993–2000 (2009).
Hadigan, C., Liebau, J., Torriani, M., Andersen, R. & Grinspoon, S. Improved triglycerides and insulin sensitivity with 3 months of acipimox in human immunodeficiency virus-infected patients with hypertriglyceridemia. J. Clin. Endocrinol. Metab. 91, 4438–4444 (2006).
Fillipas, S., Cherry, C. L., Cicuttini, F., Smirneos, L. & Holland, A. E. The effects of exercise training on metabolic and morphological outcomes for people living with HIV: a systematic review of randomised controlled trials. HIV Clin. Trials 11, 270–282 (2010).
[No authors listed] Third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (adult treatment panel III) final report. Circulation 106, 3143–3421 (2002).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Grinspoon, S., Fitch, K. HIV-associated dyslipidemia: the Heart Positive study. Nat Rev Endocrinol 7, 443–444 (2011). https://doi.org/10.1038/nrendo.2011.109
Published:
Issue date:
DOI: https://doi.org/10.1038/nrendo.2011.109