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Diabetes

RAGE links genes and environmental factors in type 1 diabetes mellitus

Nature Reviews Endocrinology volume 7, page 249 (2011)Cite this article

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Excess consumption of dietary advanced glycation end products (AGEs)—pro-oxidant metabolic derivatives of nonenzymatic reactions—may be a risk factor for type 1 diabetes mellitus (T1DM), suggest authors of a recent study in Diabetologia.

Lifestyle changes and new technologies employed in mass production over the past 50 years have increased chemical and thermal processing of foods to improve safety, transportability or flavor. However, these changes amplify the formation and ingestion of AGEs.

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ORIGINAL RESEARCH PAPER

  1. Forbes, J. M. et al. Receptor for advanced glycation end-products (RAGE) provides a link between genetic susceptibility and environmental factors in type 1 diabetes. Diabetologia doi:10.1007/s00125-011-2058-z

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  1. Linda Koch
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Koch, L. RAGE links genes and environmental factors in type 1 diabetes mellitus. Nat Rev Endocrinol 7, 249 (2011). https://doi.org/10.1038/nrendo.2011.46

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