A recent study has identified novel African-derived haplotypes, previously unreported in white people, which predispose to or are protective against type 1 diabetes mellitus (T1DM) in African Americans. These findings could have important implications for T1DM disease risk and prognosis assessment in African Americans.
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References
Noble, J. A., Johnson, J., Lane, J. A. & Valdes, A. M. HLA class II genotyping of African American type 1 diabetes patients reveals associations unique to African haplotypes. Diabetes http://dx.doi.org/10.2337/db13-0094.
Writing Group for the SEARCH for Diabetes in Youth Study Group. Incidence of diabetes in youth in the United States. JAMA 297, 2716–2724 (2007).
Noble, J. A. et al. The role of HLA class II genes in insulin-dependent diabetes mellitus: molecular analysis of 180 caucasian, multiplex families. Am. J. Hum. Genet. 59, 1134–1148 (1996).
Rewers, M. et al. Newborn screening for HLA markers associated with IDDM: diabetes autoimmunity study in the young (DAISY). Diabetologia 39, 807–812 (1996).
Lipton, R. B. et al. HLA-DQ haplotypes differ by ethnicity in patients with childhood-onset diabetes. Pediatr. Diabetes 12, 388–395 (2011).
Black, M. H. et al. HLA-associated phenotypes in youth with autoimmune diabetes. Pediatr. Diabetes 14, 121–128 (2013).
Howson, J. M., Roy, M. S., Zeitels, L., Stevens, H. & Todd, J. A. HLA class II gene associations in African American Type 1 diabetes reveal a protective HLA-DRB1*03 haplotype. Diabet. Med. 30, 710–716 (2013).
Williams, A. J. et al. Autoantibodies to islet antigen-2 are associated with HLA-DRB1*07 and DRB1*09 haplotypes as well as DRB1*04 at onset of type 1 diabetes: the possible role of HLA-DQA in autoimmunity to IA-2. Diabetologia 51, 1444–1448 (2008).
Cordovado, S. K. et al. Nephropathy in type 1 diabetes is diminished in carriers of HLA-DRB1*04: the genetics of kidneys in diabetes (GoKinD) study. Diabetes 57, 518–522 (2008).
American Diabetes Association. Standards of medical care in diabetes—2013. Diabetes Care 36 (Suppl. 1), S11–S66 (2013).
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Black, M., Dabelea, D. New HLA variants could predict T1DM risk in African Americans. Nat Rev Endocrinol 9, 570–571 (2013). https://doi.org/10.1038/nrendo.2013.160
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DOI: https://doi.org/10.1038/nrendo.2013.160
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