Finan and colleagues report a new approach to combination therapy for the metabolic syndrome—glucagon-like peptide 1 and oestradiol linked chemically to produce a fusion molecule. Treatment with this fusion molecule results in an improvement of the metabolic profile of mice with diet-induced obesity with a minimum of oestrogenic adverse effects.
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References
Finan, B. et al. Targeted estrogen delivery reverses the metabolic syndrome. Nat. Med. 18, 1847–1856 (2012).
Muller, T. D. et al. Restoration of leptin responsiveness in diet-induced obese mice using an optimized leptin analog in combination with exendin-4 or FGF21. J. Pept. Sci. 18, 383–393 (2012).
Amori, R. E., Lau, J. & Pittas, A. G. Efficacy and safety of incretin therapy in type 2 diabetes: systematic review and meta-analysis. JAMA 298, 194–206 (2007).
Le May, C. et al. Estrogens protect pancreatic beta-cells from apoptosis and prevent insulin-deficient diabetes mellitus in mice. Proc. Natl Acad. Sci. USA 103, 9232–9237 (2006).
Jones, M. E. et al. Aromatase-deficient (ArKO) mice have a phenotype of increased adiposity. Proc. Natl Acad. Sci. USA 97, 12735–12740 (2000).
Xu, Y. et al. Distinct hypothalamic neurons mediate estrogenic effects on energy homeostasis and reproduction Cell Metab. 14, 453–465 (2011).
Dunphy, J. L., Taylor, R. G. & Fuller, P. J. Tissue distribution of rat glucagon receptor and GLP-1 receptor gene expression. Mol. Cell. Endocrinol. 141, 179–186 (1998).
Gao, Q. & Horvath T. L. Cross-talk between estrogen and leptin signalling in the hypothalamus. Am. J. Physiol. Endocrinol. Metab. 294, E817–E826 (2008).
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Simpson, E., Fuller, P. Disparate bedfellows in a lasting drug union?. Nat Rev Endocrinol 9, 135–136 (2013). https://doi.org/10.1038/nrendo.2013.19
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DOI: https://doi.org/10.1038/nrendo.2013.19