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Thyroid cancer in 2013

Advances in our understanding of differentiated thyroid cancer

Studies published in 2013 have addressed the question of whether the rising incidence of differentiated thyroid cancer is actually the result of overdiagnosis. Advances have also been made in the treatment of differentiated thyroid cancer, including improvements in radioiodine therapy.

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Figure 1: A whole-body maximum-intensity projection image (from a 124I PET–CT scan) of a patient with a BRAF-mutant papillary thyroid cancer before and after treatment with selumetinib.

References

  1. Franssila, K. O. & Harach, H. R. Occult papillary carcinoma of the thyroid in children and young adults. A systemic autopsy study in Finland. Cancer 58, 715–719 (1986).

    Article  CAS  PubMed  Google Scholar 

  2. Udelsman, R. & Zhang, Y. The epidemic of thyroid cancer in the United States: the role of endocrinologists and ultrasounds. Thyroid http://dx.doi.org/10.1089/thy.2013.0257.

  3. Li, N., Du, X. L., Reitzel, L. R., Xu, L. & Sturgis, E. M. Impact of enhanced detection on the increase in thyroid cancer incidence in the United States: review of incidence trends by socioeconomic status within the surveillance, epidemiology, and end results registry, 1980–2008. Thyroid 23, 103–110 (2013).

    Article  PubMed  PubMed Central  Google Scholar 

  4. Morris, L. G., Sikora, A. G., Tosteson, T. D. & Davies, L. The increasing incidence of thyroid cancer: the influence of access to care. Thyroid 23, 885–891 (2013).

    Article  PubMed  PubMed Central  Google Scholar 

  5. Guay, B., Johnson-Obaseki, S. E., McDonald, J. T., Connell, C. & Corsten, M. Incidence of differentiated thyroid cancer by socioeconomic status and urban residence: Canada 1991–2006. Thyroid http://dx.doi.org/10.1089/thy.2013.0308.

  6. Lee, T. J., Kim, S., Cho, H. J. & Lee, J. H. The incidence of thyroid cancer is affected by the characteristics of a healthcare system. J. Korean Med. Sci. 27, 1491–1498 (2012).

    Article  PubMed  PubMed Central  Google Scholar 

  7. Sabra, M. M. et al. Clinical outcomes and molecular profile of differentiated thyroid cancers with radioiodine-avid distant metastases. J. Clin. Endocrinol. Metab. 98, E829–E836 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Ho, A. L. et al. Selumetinib-enhanced radioiodine uptake in advanced thyroid cancer. N. Engl. J. Med. 368, 623–632 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Reiners, C. et al. Twenty-five years after Chernobyl: outcome of radioiodine treatment in children and adolescents with very high-risk radiation-induced differentiated thyroid carcinoma. J. Clin. Endocrinol. Metab. 98, 3039–3048 (2013).

    Article  CAS  PubMed  Google Scholar 

  10. Kim, C. et al. The risk of second cancers after diagnosis of primary thyroid cancer is elevated in thyroid microcarcinomas. Thyroid 23, 575–582 (2013).

    Article  PubMed  PubMed Central  Google Scholar 

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Correspondence to Christoph Reiners.

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Reiners, C. Advances in our understanding of differentiated thyroid cancer. Nat Rev Endocrinol 10, 69–70 (2014). https://doi.org/10.1038/nrendo.2013.247

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