Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Research Highlight
  • Published:

Neuroendocrinology

Role for adiponectin in effects of exercise in depression

Nature Reviews Endocrinology volume 11, page 4 (2015)Cite this article

Subjects

Access through your institution
Buy or subscribe

New research in mice suggests that raised levels of adiponectin as a result of exercise modulate hippocampal neurogenesis, thus decreasing depression-like behaviours.

Previous work in rats has shown that voluntary running increases plasma levels of adiponectin, with a concurrent decrease in depression-like behaviours. However, the exact mechanisms underlying the positive effects of exercise on depression are unclear. These observations led a team of researchers from China to “explore whether adiponectin could be the key mediator of the antidepressant effect of physical exercise,” explain corresponding authors Aimin Xu and Kwok-Fai So.

This is a preview of subscription content, access via your institution

Access options

Access through your institution

Buy this article

  • Purchase on SpringerLink
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Yau, S. Y. et al. Physical exercise-induced hippocampal neurogenesis and antidepressant effects are mediated by the adipocyte hormone adiponectin. Proc. Natl Acad. Sci. USA 10.1073/pnas.1415219111

Download references

Authors
  1. Claire Greenhill
    View author publications

    Search author on:PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Greenhill, C. Role for adiponectin in effects of exercise in depression. Nat Rev Endocrinol 11, 4 (2015). https://doi.org/10.1038/nrendo.2014.201

Download citation

  • Published:

  • Issue date:

  • DOI: https://doi.org/10.1038/nrendo.2014.201

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing