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Diabetes

Epigenetic changes lead to impaired wound healing in patients with T2DM

Nature Reviews Endocrinology volume 11, page 65 (2015)Cite this article

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Patients with type 2 diabetes mellitus (T2DM) have impaired wound healing owing to the dominance of the proinflammatory M1 macrophage phenotype. New research reveals that, under diabetic conditions, lysine-specific demethylase 6B (also known as JMJD3) demethylates the lysine 27, histone 3 (H3K27Me3) mark that supresses IL-12 expression, which results in increased IL-12 production and polarization of macrophages to an M1 phenotype.

“Macrophages isolated from patients with T2DM produce excess proinflammatory mediators; however, the molecular mechanisms that programme and sustain these phenotypes were unclear,” explains lead author Katherine Gallagher.

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References

  1. Gallagher, K. A. et al. Epigenetic changes in bone marrow progenitor cells influence the inflammatory phenotype and alter wound healing in type 2 diabetes. Diabetes 10.2337/db14-0872

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  1. Peter Sidaway
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Sidaway, P. Epigenetic changes lead to impaired wound healing in patients with T2DM. Nat Rev Endocrinol 11, 65 (2015). https://doi.org/10.1038/nrendo.2014.207

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