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Thyroid function

Inactivation of T3 in muscle stem cells

Nature Reviews Endocrinology volume 11, page 65 (2015)Cite this article

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New research reveals that type 3 deiodinase is upregulated in muscle stem cells in response to acute skeletal muscle injury, which reduces intracellular T3 signalling.

Domenico Salvatore and colleagues developed a dio3-floxed mouse model to selectively ablate type 3 deiodinase in the muscle stem cell compartment. Skeletal muscle regeneration was found to be severely impaired in these mice. Salvatore and co-workers determined that this impairment was due to apoptosis of muscle stem cells as a result of high intracellular levels of T3.

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References

  1. Dentice, M. et al. Intracellular inactivation of thyroid hormone is a survival mechanism for muscle stem cell proliferation and lineage progression. Cell Metab. 10.1016/j.cmet.2014.10.009

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Authors
  1. Claire Greenhill
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Greenhill, C. Inactivation of T3 in muscle stem cells. Nat Rev Endocrinol 11, 65 (2015). https://doi.org/10.1038/nrendo.2014.211

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