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Immunology

Follicular helper T cells in T1DM

Nature Reviews Endocrinology volume 11, page 65 (2015)Cite this article

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New research published in the Journal of Clinical Investigation demonstrates that patients with type 1 diabetes mellitus (T1DM) have cellular and molecular indicators of the presence of follicular helper T (Tfh) cells, which might drive disease pathogenesis upstream of autoantibody generation.

The mechanisms underlying the immunopathogenesis of T1DM have been the focus of intensive research. Previously, findings from studies performed in animal models suggested that the type 1 helper T cell subset of CD4+ T helper cells was primarily responsible for autoimmune destruction of the pancreas in T1DM. Our understanding of the nuances of T helper cell differentiation, and the phenotypes and functions of the subsets, has considerably advanced in the past decade. Now, a team of researchers led by senior investigator Lucy Walker at University College London, UK, show that Tfh differentiation and skewing towards a Tfh phenotype might contribute to development of autoimmunity in T1DM.

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References

  1. Kenefeck, R. et al. Follicular helper T cell signature in type 1 diabetes. J. Clin. Invest. 10.1172/JCI76238

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  1. Jennifer Sargent
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Sargent, J. Follicular helper T cells in T1DM. Nat Rev Endocrinol 11, 65 (2015). https://doi.org/10.1038/nrendo.2014.216

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