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Immunology

The control of homeostasis in adipose tissue

Nature Reviews Endocrinology volume 11, page 66 (2015)Cite this article

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A new study published in Nature Immunology demonstrates that invariant natural killer T (iNKT) cells in adipose tissue from normal-weight mice and humans produce IL-2 and IL-10, which enables the cells to maintain an anti-inflammatory macrophage phenotype and control the activity of regulatory T cells. iNKT cells are, therefore, regulators of immunological homeostasis in adipose tissue that could be targeted in the treatment of obesity and other metabolic disorders, according to the authors of the study.

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References

  1. Lynch, L. et al. Regulatory iNKT cells lack expression of the transcription factor PLZF and control the homeostasis of Treg cells and macrophages in adipose tissue. Nat. Immunol. 10.1038/ni.3047

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The control of homeostasis in adipose tissue. Nat Rev Endocrinol 11, 66 (2015). https://doi.org/10.1038/nrendo.2014.225

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