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Immunology

ILC2s regulate obesity and drive beiging of white adipose tissue

Nature Reviews Endocrinology volume 11, page 131 (2015)Cite this article

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A new function of group 2 innate lymphoid cells (ILC2s) in limiting obesity via the beiging of white adipose tissue (WAT) has been published in Nature.

A growing body of evidence from studies in animal models support a role for immune cells in regulating metabolic homeostasis; however, a similar role has not been demonstrated in humans. Now, researchers at Cornell University, USA, have shown that ILC2s are present in WAT in both humans and mice. Furthermore, the number of these cells is reduced in abdominal fat of individuals with obesity compared with that of non-obese individuals, and is lower in epididymal WAT of mice fed a high-fat diet than mice fed a control diet.

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References

  1. Brestoff, J. R. et al. Group 2 innate lymphoid cells promote beiging of adipose and limit obesity. Nature 1038/nature14115

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Authors
  1. Jennifer Sargent
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Sargent, J. ILC2s regulate obesity and drive beiging of white adipose tissue. Nat Rev Endocrinol 11, 131 (2015). https://doi.org/10.1038/nrendo.2014.233

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  • DOI: https://doi.org/10.1038/nrendo.2014.233

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