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Therapy

Cortisol rhythms in Addison disease

Nature Reviews Endocrinology volume 10, page 250 (2014)Cite this article

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Continuous subcutaneous hydrocortisone infusion (CSHI) may provide a safe alternative treatment for patients with Addison disease who do not respond favourably to oral hydrocortisone therapy, show the results of a new clinical trial.

Oral hydrocortisone therapy is the most widely used treatment strategy for patients with Addison disease undergoing glucocorticoid replacement. Some patients, however, respond adversely to this treatment. “Health-related quality of life is reduced in patients with Addison disease, and some studies indicate increased mortality in these patients,” adds Marianne Øksnes, lead author of the study. “Oral replacement therapy could possibly predispose patients to long-term adverse metabolic disorders such as osteoporosis and cardiovascular disease.”

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References

  1. Øksnes, M. et al. Continuous subcutaneous hydrocortisone infusion versus oral hydrocortisone replacement for treatment of Addison's disease: a randomized clinical trial. J. Clin. Endocrinol. Metab. 10.1210/jc.2013-4253

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  1. Jennifer Sargent
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Sargent, J. Cortisol rhythms in Addison disease. Nat Rev Endocrinol 10, 250 (2014). https://doi.org/10.1038/nrendo.2014.25

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