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Thyroid gland

Unlocking the potential of thyroid autoantibodies

Nature Reviews Endocrinology volume 10, page 314 (2014)Cite this article

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Two new studies highlight the value of thyroid autoantibodies in predicting both the risk of developing differentiated thyroid cancer (DTC) and the long-term outcome of patients with DTC.

Thyroid autoantibodies are characteristic of Hashimoto thyroiditis, and are associated with lymphocytic infiltration and destruction of the thyroid gland, leading to hypothyroidism. However, the relationship between Hashimoto thyroiditis and DTC is controversial. In particular, debate is ongoing as to whether the inflammation in Hashimoto thyroiditis is a cause or consequence of DTC. Additionally, the effect of inflammation on the outcome of patients with DTC is uncertain.

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References

  1. Paparodis, R. et al. Hashimoto thyroiditis pathology and risk for thyroid cancer. Thyroid 10.1089/thy.2013.0588

  2. Durante, C. et al. Clinical aggressiveness and long-term outcome in patients with papillary thyroid cancer and circulating anti-thyroglobulin autoantibodies. Thyroid 10.1089/thy.2013.0698

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Authors
  1. David Holmes
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Holmes, D. Unlocking the potential of thyroid autoantibodies. Nat Rev Endocrinol 10, 314 (2014). https://doi.org/10.1038/nrendo.2014.63

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