Trial sequential meta-analysis of data from 20 existing randomized controlled trials that included a total of 29,535 participants showed that supplementation with vitamin D does not result in a reduction of the risk of falls by >15%. The effect estimate of vitamin D supplementation, with and without calcium, on falls lay within the futility boundary. The authors state that their results suggest that further trials investigating these effects are unwarranted.
References
Bolland, M. J. et al. Vitamin D supplementation and falls: a trial sequential meta-analysis. Lancet Diabetes Endocrinol. 10.1016/S2213-8587(14)70068-3
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Vitamin D supplementation is ineffective in fall prevention. Nat Rev Endocrinol 10, 380 (2014). https://doi.org/10.1038/nrendo.2014.69
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DOI: https://doi.org/10.1038/nrendo.2014.69
