Integrated genomic analysis has revealed two distinct molecular subsets of adrenocortical carcinomas (ACCs) with opposite clinical outcomes. Exome sequencing and single nucleotide polymorphism array analyses were performed on 45 ACCs and the findings validated in an independent cohort of 77 ACCs. Novel mutations were identified in genes previously not associated with ACCs, including ZNRF3, DAXX, TERT and MED12. A group of ACCs with poor outcomes harboured multiple genetic mutations and changes in DNA methylation, whereas ACCs with good prognosis were characterized by specific deregulation of two microRNA clusters.
References
Assié, G. et al. Integrated genomic characterization of adrenocortical carcinoma. Nat. Genet. 10.1038/ng.2953
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Newly identified genetic mutations are associated with distinct adrenal tumour subtypes. Nat Rev Endocrinol 10, 380 (2014). https://doi.org/10.1038/nrendo.2014.70
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DOI: https://doi.org/10.1038/nrendo.2014.70
