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Risk factors

Prepregnancy GGT levels predict risk of gestational diabetes mellitus

Nature Reviews Endocrinology volume 10, page 378 (2014)Cite this article

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Gestational diabetes mellitus (GDM) increases the risk of developing type 2 diabetes mellitus (T2DM) after pregnancy. Novel findings show that high serum levels of γ-glutamyltransferase (GGT) measured many years before pregnancy are a risk factor for development of GDM.

A team of researchers at Kaiser Permanente Northern California (Oakland, USA) set out to investigate whether women who develop GDM already have metabolic abnormalities in the years before they become pregnant. In this study, they specifically focused on liver enzymes, whose levels have been associated with insulin resistance and T2DM in other populations.

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References

  1. Sridhar, S. B. et al. Pregravid liver enzyme levels and risk of gestational diabetes during a subsequent pregnancy. Diabetes Care 10.2337/dc13-2229

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  1. Joana Osório
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Osório, J. Prepregnancy GGT levels predict risk of gestational diabetes mellitus. Nat Rev Endocrinol 10, 378 (2014). https://doi.org/10.1038/nrendo.2014.79

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