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Nutrition

Obesity causes irreversible loss of olfaction

Nature Reviews Endocrinology volume 10, page 446 (2014)Cite this article

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Obesity in mice that was induced by exposure to a high-fat diet (HFD) resulted in loss of olfactory sensory neurons, reduced olfactory discrimination and disruption of odour-reversal learning. Obese mice exhibited reduced ability to learn reward-reinforced behaviours and had increased overall behavioural inflexibility. When the mice were removed from the HFD feeding regime and allowed to return to normal weight, the olfactory dysfunctions that were associated with obesity did not resolve, suggesting that long-lasting functional changes had occurred.

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References

  1. Thiebaud, N. et al. Hyperlipidemic diet causes loss of olfactory sensory neurons, reduces olfactory discrimination, and disrupts odor-reversal learning. J. Neurosci. 10.1523/jneurosci.3366-13.2014

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Obesity causes irreversible loss of olfaction. Nat Rev Endocrinol 10, 446 (2014). https://doi.org/10.1038/nrendo.2014.85

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