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Epigenetics

Obesity-induced hypermethylation of adiponectin gene

Nature Reviews Endocrinology volume 11, page 504 (2015)Cite this article

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The mechanisms underlying obesity-induced dysregulation of the gene that encodes adiponectin (ADIPOQ) have been revealed in a new paper published in Nature Communications.

Adiponectin controls the metabolism of glucose and insulin, and its levels are decreased in obesity. However, the mechanism by which expression of ADIPOQ is reduced in obesity is unknown. Jae Bum Kim and colleagues speculated that epigenetic changes could be involved in the suppression of ADIPOQ expression in obesity.

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References

  1. Kim, A. Y. et al. Obesity-induced DNA hypermethylation of the adiponectin gene mediates insulin resistance. Nat. Commun. 10.1038/ncomms8585

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  1. Claire Greenhill
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Greenhill, C. Obesity-induced hypermethylation of adiponectin gene. Nat Rev Endocrinol 11, 504 (2015). https://doi.org/10.1038/nrendo.2015.116

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