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Diabetes

Enterovirus dysregulates islet miRNAs

Nature Reviews Endocrinology volume 12, page 2 (2016)Cite this article

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Human pancreatic islets infected in vitro with coxsackievirus B5 (CVB5, a common serotype of the coxsackievirus B subtype of enterovirus B) show dysregulated expression of 33 microRNAs (miRNAs), according to new results published in Diabetes. Functional analysis predicts that these miRNAs target numerous risk genes for type 1 diabetes mellitus (T1DM).

“Strong epidemiological evidence and a large body of molecular data provide compelling support for the viral aetiology of T1DM,” explains author Ki Wook Kim. “Many viruses ... alter the function of host miRNAs and enterovirus infection disrupts the activity of multiple miRNAs in rodent pancreatic β cells.” Important functions of islet β cells, such as glucose sensing, insulin release and apoptosis, are regulated by miRNAs, and Kim and colleagues hypothesized that CVB5 infection in human islets would alter miRNA expression, providing a mechanistic link between viral infection and the development of T1DM.

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References

  1. Kim, K. W. et al. Coxsackievirus B5 infection induces dysregulation of microRNAs predicted to target known type 1 diabetes risk genes in human pancreatic islets. Diabetes http://dx.doi.org/10.2337/db15-0956

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  1. Hugh Thomas
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Thomas, H. Enterovirus dysregulates islet miRNAs. Nat Rev Endocrinol 12, 2 (2016). https://doi.org/10.1038/nrendo.2015.210

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  • DOI: https://doi.org/10.1038/nrendo.2015.210

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