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Diabetes

Brain changes in T1DM—a microvascular complication?

Nature Reviews Endocrinology volume 11, pages 447–448 (2015)Cite this article

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A recent study indicates that type 1 diabetes mellitus is associated with vascular brain lesions that affect cognition and might represent a target for preventive measures. This commentary discusses methods to ascertain vascular contributions to cerebral dysfunction in diabetes mellitus and indicates that we might only be seeing the tip of the iceberg.

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References

  1. Koekkoek, P. S., Kappelle, L. J., van den Berg, E., Rutten, G. E. & Biessels, G. J. Cognitive function in patients with diabetes mellitus: guidance for daily care. Lancet Neurol. 14, 329–340 (2015).

    Article  Google Scholar 

  2. Biessels, G. J., Strachan, M. W., Visseren, F. L., Kappelle, L. J. & Whitmer, R. A. Dementia and cognitive decline in type 2 diabetes and prediabetic stages: towards targeted interventions. Lancet Diabetes Endocrinol. 2, 246–255 (2014).

    Article  Google Scholar 

  3. Biessels, G. J. & Reijmer, Y. D. Brain changes underlying cognitive dysfunction in diabetes: what can we learn from MRI? Diabetes 63, 2244–2252 (2014).

    Article  Google Scholar 

  4. Nelson, P. T. et al. Human cerebral neuropathology of type 2 diabetes mellitus. Biochim. Biophys. Acta 1792, 454–469 (2009).

    Article  CAS  Google Scholar 

  5. Nunley, K. A. et al. White matter hyperintensities in middle-aged adults with childhood-onset type 1 diabetes. Neurology 84, 2062–2069 (2015).

    Article  CAS  Google Scholar 

  6. Barnea-Goraly, N. et al. Alterations in white matter structure in young children with type 1 diabetes. Diabetes Care 37, 332–340 (2013).

    Article  Google Scholar 

  7. Mauras, N. et al. Longitudinal assessment of neuroanatomical and cognitive differences in young children with type 1 diabetes: association with hyperglycemia. Diabetes 64, 1770–1779 (2015).

    Article  CAS  Google Scholar 

  8. Wardlaw, J. M. et al. Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration. Lancet Neurol. 12, 822–838 (2013).

    Article  Google Scholar 

  9. Wardlaw, J. M., Smith, C. & Dichgans, M. Mechanisms of sporadic cerebral small vessel disease: insights from neuroimaging. Lancet Neurol. 12, 483–497 (2013).

    Article  Google Scholar 

  10. Brundel, M. et al. Cerebral microvascular lesions on high-resolution 7-tesla MRI in patients with type 2 diabetes. Diabetes 63, 3523–3529 (2014).

    Article  CAS  Google Scholar 

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Acknowledgements

G.J.B. would like to acknowledge the support of grant 2010T073 from the Dutch Heart Association and Vidi grant 91711384 from ZonMw, The Netherlands Organisation for Health Research and Development.

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Authors and Affiliations

  1. Department of Neurology, G03.232, University Medical Center, PO Box 85500, Utrecht, 3508 GA, Netherlands

    Geert Jan Biessels

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  1. Geert Jan Biessels
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Correspondence to Geert Jan Biessels.

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Competing interests

G.J.B. consults for and receives research support from Boehringer Ingelheim and consults for Takeda Pharmaceuticals. Compensation for these services is transferred to his employer, the UMC Utrecht.

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Biessels, G. Brain changes in T1DM—a microvascular complication?. Nat Rev Endocrinol 11, 447–448 (2015). https://doi.org/10.1038/nrendo.2015.93

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