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Adipose tissue

Direct beige-to-white conversion

Nature Reviews Endocrinology volume 12, page 626 (2016)Cite this article

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New research published in Cell Metabolism has uncovered the mechanism underlying the maintenance of beige adipocytes. The findings could lead to new approaches for the treatment of obesity.

“While previous studies have suggested that beige fat disappears once external stimuli such as cold are removed, the underlying mechanism by which beige adipocytes disappear has, until now, remained completely unknown,” explains lead investigator Shingo Kajimura of the University of California, San Francisco. “We set out to understand the mechanisms of beige adipocyte maintenance, with a view to developing new approaches for maintaining beige fat for longer.”

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References

  1. Altshuler-Keylin, S. et al. Beige adipocyte maintenance is regulated by autophagy-induced mitochondrial clearance. Cell Metab. http://dx.doi.org/10.1016/j.cmet.2016.08.002 (2016)

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  1. David Holmes
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Holmes, D. Direct beige-to-white conversion. Nat Rev Endocrinol 12, 626 (2016). https://doi.org/10.1038/nrendo.2016.159

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