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Inflammation in patients with Cushing disease

Nature Reviews Endocrinology volume 12, page 687 (2016)Cite this article

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Circulating levels of proinflammatory cytokines are increased in patients with Cushing disease, both during active disease and after remission, according to new data published in Clinical Endocrinology.

Glucocorticoids (which are elevated in patients with Cushing disease) are known to have anti-inflammatory properties. Despite these effects, patients with Cushing disease often have obesity, insulin resistance and cardiovascular disease, which are all associated with inflammation. Furthermore, patients with Cushing disease have an increased risk of cardiovascular-related death, even after remission. Previous studies investigating these phenomena have been inconclusive. This study, led by Eliza Geer from the Icahn School of Medicine at Mount Sinai, USA, was designed to investigate inflammation in patients with Cushing disease.

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References

  1. Shah, N. et al. Pro-inflammatory cytokines remain elevated despite long-term remission in Cushing's disease: a prospective study. Clin. Endocrinol. (Oxf.) http://dx.doi.org/10.1111/cen.13230 (2016)

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  1. Claire Greenhill
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Greenhill, C. Inflammation in patients with Cushing disease. Nat Rev Endocrinol 12, 687 (2016). https://doi.org/10.1038/nrendo.2016.170

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