Figure 2: Proposed workflow for re-evaluation of genetic variants detected in phaeochromocytomas and/or paragangliomas (PPGLs).
An annual review of variants might lead to re-classification based on new research and/or clinical evidence, with an effect on clinical follow up and screening of at-risk family members. Class 1 (not pathogenic), class 2 (likely not pathogenic), class 3 (variant of unknown significance), class 4 (likely pathogenic), class 5 (pathogenic).
