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Gut microbiota promote bone growth via IGF1

Nature Reviews Endocrinology volume 13, page 5 (2017)Cite this article

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Presence of the gut microbiota increases circulating levels of insulin-like growth factor 1 (IGF1) and supports bone growth, according to a new study in mice.

Bone mass is an important determinant of the increased risk of bone fracture with age. The gut microbiota exhibit enhanced diversity and reduced stability with age, but findings have conflicted whether the microbiota promote bone growth or resorption.

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References

  1. Yan, J. et al. Gut microbiota induce IGF-1 and promote bone formation and growth. Proc. Natl. Acad. Sci. http://dx.doi.org/10.1073/pnas.1607235113 (2016)

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  1. Charlotte Ridler
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Ridler, C. Gut microbiota promote bone growth via IGF1. Nat Rev Endocrinol 13, 5 (2017). https://doi.org/10.1038/nrendo.2016.200

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