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Adipose tissue

Noncanonical beige fat thermogenesis

Nature Reviews Endocrinology volume 14, page 2 (2018)Cite this article

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Uncoupling protein 1 (UCP1) has long been considered the sole mediator of beige thermogenesis and its associated metabolic effects. A new study challenges this dogma by reporting a noncanonical, UCP1-independent thermogenic mechanism in beige fat that controls whole-body energy homeostasis.

Mice with transgenic expression of Prdm16 (Prdm16Tg; which increases beige fat mass) were crossed with Ucp1−/− mice. “This model allowed us to determine the extent to which beige fat function depends on UCP1,” explains lead investigator Shingo Kajimura.

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References

  1. Ikeda, K. et al. UCP1-independent signaling involving SERCA2b-mediated calcium cycling regulates beige fat thermogenesis and systemic glucose homeostasis. Nat. Med. http://dx.doi.org/10.1038/nm.4429 (2017)

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  1. Conor A. Bradley
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Bradley, C. Noncanonical beige fat thermogenesis. Nat Rev Endocrinol 14, 2 (2018). https://doi.org/10.1038/nrendo.2017.158

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