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Diabetes

Very-low-calorie diet reverses T2DM in rats

Nature Reviews Endocrinology volume 14, page 2 (2018)Cite this article

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...Perry and colleagues show that a VLCD reverses T2DM via a combination of three beneficial effects on hepatic glucose metabolism.

Studies in animal models have previously demonstrated that a very-low-calorie diet (VLCD) is just as effective at reducing plasma glucose concentrations as bariatric surgery. These findings suggest that the forced caloric restriction that occurs with bariatric surgery is the reason for the effect of bariatric surgery on the symptoms of type 2 diabetes mellitus (T2DM), but the molecular mechanisms have remained unclear. Now, Gerald Shulman, Rachel Perry and colleagues show that a VLCD reverses T2DM via a combination of three beneficial effects on hepatic glucose metabolism.

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References

  1. Perry, R. J. et al. Mechanisms by which a very-low-calorie diet reverses hyperglycemia in a rat model of type 2 diabetes. Cell Metab. http://dx.doi.org/10.1016/j.cmet.2017.10.004 (2017)

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  1. Alan Morris
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Petersen, M. C. et al. Regulation of hepatic glucose metabolism in health and disease. Nat. Rev. Endocrinol. 13, 572–587 (2017)

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Morris, A. Very-low-calorie diet reverses T2DM in rats. Nat Rev Endocrinol 14, 2 (2018). https://doi.org/10.1038/nrendo.2017.159

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