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Immunotherapy

PDL1 restoration reverses T1DM

Nature Reviews Endocrinology volume 14, page 1 (2018)Cite this article

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Most immunotherapy approaches to cure type 1 diabetes mellitus (T1DM) tested to date have failed, probably owing to lack of specificity. However, the transplantation of autologous haematopoietic stem and progenitor cells (HSPCs) has shown promise. “This led us to further explore this field and focus our studies on characterizing HSPCs in T1DM and in nonobese diabetic (NOD) mice,” explains lead investigator Paolo Fiorina.

restoration of PDL1 is a viable immunotherapy

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References

  1. Ben Nasr, M. et al. PD-L1 genetic overexpression or pharmacological restoration in hematopoietic stem and progenitor cells reverses autoimmune diabetes. Sci. Transl. Med. http://dx.doi.org/10.1126/scitranslmed.aam7543 (2017)

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  1. Conor A. Bradley
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Bradley, C. PDL1 restoration reverses T1DM. Nat Rev Endocrinol 14, 1 (2018). https://doi.org/10.1038/nrendo.2017.165

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