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Diabetes

ANGPTL8 as an early predictor of gestational diabetes mellitus

Nature Reviews Endocrinology volume 14, page 64 (2018)Cite this article

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In the clinic, effective biomarkers for predicting GDM are currently lacking. Clinicians currently rely on an assessment of established maternal risk factors for GDM, such as age at pregnancy and family history of diabetes mellitus, in combination with a 75 g oral glucose tolerance test (OGTT), which is the gold standard for diagnosing GDM. The OGTT, however, cannot be conducted until late in the second trimester, which can result in a developing fetus being exposed to hyperglycaemic conditions for a long period of time.

Plasma levels of ANGPTL8 are associated with insulin resistance, and a preliminary study conducted by Fang, Hu and colleagues showed that levels of ANGPTL8 in the plasma are elevated in pregnant women during the second trimester. Based on these results, the authors speculated that the levels of ANGPTL8 in the plasma of women who develop GDM might increase in early pregnancy and be linked to the development of insulin resistance.

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References

  1. Huang, Y. et al. Angiopoietin-like protein 8 in early pregnancy improves the prediction of gestational diabetes. Diabetologia http://dx.doi.org/10.1007/s00125-017-4505-y (2017)

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  1. Ivone Leong
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Leong, I. ANGPTL8 as an early predictor of gestational diabetes mellitus. Nat Rev Endocrinol 14, 64 (2018). https://doi.org/10.1038/nrendo.2017.167

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