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Thyroid function

Thyroid hormone therapy resolves pulmonary fibrosis in mice

Nature Reviews Endocrinology volume 14, page 64 (2018)Cite this article

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Naftali Kaminski and colleagues have used thyroid hormone therapy to resolve established fibrosis in two mouse models of lung fibrosis

Idiopathic pulmonary fibrosis (IPF) is the scarring and destruction of the lung caused by the accumulation of excessive amounts of extracellular matrix, which is secreted by abnormally activated alveolar epithelial cells. Following up on their observation that the expression of DIO2 — which encodes the enzyme that converts T4 into T3 — is markedly increased in the lungs of patients with IPF, Guoying Yu, Argyris Tzouvelekis, Naftali Kaminski and colleagues have used thyroid hormone therapy to resolve established fibrosis in two mouse models of lung fibrosis.

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References

  1. Yu, G. et al. Thyroid hormone inhibits lung fibrosis in mice by improving epithelial mitochondrial function. Nat. Med. http://dx.doi.org/10.1038/nm.4447 (2017)

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  1. Alan Morris
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Morris, A. Thyroid hormone therapy resolves pulmonary fibrosis in mice. Nat Rev Endocrinol 14, 64 (2018). https://doi.org/10.1038/nrendo.2017.172

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