Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Research Highlight
  • Published:

Transcription

Intragenic enhancers dampen gene expression

Nature Reviews Genetics volume 18, page 703 (2017)Cite this article

Subjects

transcription from intragenic enhancers can attenuate transcription of the host gene

By analysing published Pol II chromatin immunoprecipitation followed by sequencing (ChIP–seq) data from mouse embryonic stem cells (ESCs), the authors identified 1,928 intragenic RNA Pol II sites (IRSs) — that is, intragenic sites enriched for Pol II binding. IRSs had chromatin signatures typical of enhancers, bound to transcription factors that commonly bind to enhancers and enhanced gene expression in reporter assays. Thus, IRSs seem to be transcriptionally active intragenic enhancers.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on SpringerLink
  • Instant access to the full article PDF.

USD 39.95

Prices may be subject to local taxes which are calculated during checkout

References

  1. Cinghu, S. et al. Intragenic enhancers attenuate host gene expression. Mol. Cell 68, 104–117 (2017)10.1016/j.molcel.2017.09.010

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Authors
  1. Katharine H. Wrighton
    View author publications

    Search author on:PubMed Google Scholar

Related links

Related links

Related links in Nature Research

Li, W., Notani, D. & Rosenfeld, M. G. Enhancers as non-coding RNA transcription units: recent insights and future perspectives. Nat. Rev. Genet. 17, 207–223 (2016)

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Wrighton, K. Intragenic enhancers dampen gene expression. Nat Rev Genet 18, 703 (2017). https://doi.org/10.1038/nrg.2017.90

Download citation

  • Published:

  • Issue date:

  • DOI: https://doi.org/10.1038/nrg.2017.90

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing