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Gene expression

Something for a stressful day

Nature Reviews Genetics volume 6, page 876 (2005)Cite this article

Intrigued by the earlier observation that poly(A)+ RNA is enriched in distinct subnuclear structures known as nuclear speckles, the Spector group set out to isolate and characterize the population of poly(A)+ RNA molecules in nuclear speckles. They showed that one RNA — which they named CTN-RNA, and is encoded by the mouse cationic amino-acid transporter 2 (Cat2; also known as Slc7a2 ) gene — colocalizes only partially with nuclear speckles, but colocalizes completely with adjacent nuclear domains, known as paraspeckles.

The mechanism for nuclear retention of RNA molecules is unknown, but it could occur as a result of an RNA-editing process known as adenosine (A) to inosine (I) editing. Could CTN-RNA be a target for RNA editing? Sequence comparison of several CTN-RNA clones revealed that A-to-I editing takes place in the 3′ UTR. However, reporter-gene analysis showed that the CTN-RNA 3′ UTR is not sufficient for retention, but that the entire transcript is required. This could indicate that specific folding of the entire RNA, as well as A-to-I editing of the 3′ UTR, is important for nuclear retention.

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References

ORIGINAL RESEARCH PAPER

  1. Prasanth, K. V. et al. Regulating gene expression through RNA nuclear retention. Cell 123, 249–263 (2005)

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FURTHER READING

  1. Bass, B. L. et al. A nuclear RNA is cut out for translation. Cell 123, 181–183 (2005)

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  1. Chief Editor, Nature Reviews Molecular Cell Biology,

    Arianne Heinrichs

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  1. Arianne Heinrichs
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Heinrichs, A. Something for a stressful day. Nat Rev Genet 6, 876 (2005). https://doi.org/10.1038/nrg1753

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