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Genome evolution

A manual way to the ancestral genome

Nature Reviews Genetics volume 10, page 426 (2009)Cite this article

The authors compared genome data from the Yeast Gene Order Browser (YGOB) of five post-WGD yeast species (descended from the ancestor that underwent WGD) and six non-WGD yeast species. They visually comparedoverlapping 25-gene windows across the genomes to find breaks in synteny and deduce the ancestral gene order.

Their method inferred an ancestral genome with 8 chromosomes and 4,703 protein-coding genes, which can be viewed on the YGOB website. The authors acknowledge that their method cannot cover telomeric regions, genes that were transposed at approximately the same time as the WGD or genes that were lost in all post-WGD species after the WGD event.

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References

ORIGINAL RESEARCH PAPER

  1. Gordon, J. L., Byrne, K. P. & Wolfe, K. H. Additions, losses, and rearrangements on the evolutionary route from a reconstructed ancestor to the modern Saccharomyces cerevisiae genome. PLoS Genet. 5, e1000485 (2009)

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FURTHER READING

  1. Conant, G. C. & Wolfe, K. H. Turning a hobby into a job: how duplicated genes find new functions. Nature Rev. Genet. 9, 938–950 (2008)

    Article  CAS  Google Scholar 

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Authors
  1. Elizabeth Neame
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Yeast Gene Order Browser

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Neame, E. A manual way to the ancestral genome. Nat Rev Genet 10, 426 (2009). https://doi.org/10.1038/nrg2619

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  • DOI: https://doi.org/10.1038/nrg2619

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