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Synthetic biology

Avoiding the chop

Nature Reviews Genetics volume 10, page 660 (2009)Cite this article

J. Craig Venter and colleagues previously demonstrated that the genome of one bacterium could be replaced with that of another and reasoned that the same would be true for a synthetic genome. However, when they chemically synthesized a bacterial genome, assembled it in a yeast system and tried to transplant the synthetic genome into a different recipient strain, they were unable to recover any transformed cells.

...the maintenance of bacterial genomes in yeast described in this study will allow the manipulation of bacterial genomes...

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References

ORIGINAL RESEARCH PAPER

  1. Lartigue, C. et al. Creating bacterial strains from genomes that have been cloned and engineered in yeast. Science 20 Aug 2009 (doi:10.1126/science.1173759)

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FURTHER READING

  1. Benner, S. A. & Sismour, A. M. Synthetic biology. Nature Rev. Genet. 6, 533–543 (2005)

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Authors
  1. Meera Swami
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Swami, M. Avoiding the chop. Nat Rev Genet 10, 660 (2009). https://doi.org/10.1038/nrg2671

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