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Transcriptional regulation

Non-cooperative transcriptional control

Nature Reviews Genetics volume 11, page 240 (2010)Cite this article

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Giorgetti and colleagues studied transcriptional regulation by the inflammatory transcription factor nuclear factor-κB (NF-κB). In a genome-wide analysis of NF-κB binding sites in the human genome, they found that clusters of NF-κB binding sites are a common occurrence in the upstream regions of NF-κB target genes, including NF-κΒ family members themselves and negative regulators of NF-κB activity.

What effect do these clusters have on the NF-κB transcriptional response? The authors found that genes with clustered NF-κB binding sites responded to an increasing gradient of nuclear NF-κB concentration by gradually increasing transcription — an analogue response rather than a digital one.

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References

ORIGINAL RESEARCH PAPER

  1. Giorgetti, L. et al. Noncooperative interactions between transcription factors and clustered DNA binding sites enable graded transcriptional responses to environmental inputs. Mol. Cell 37, 418–428 (2010)

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FURTHER READING

  1. Segal, E. & Widom, J. From DNA sequence to transcriptional behaviour: a quantitative approach. Nature Rev. Genet. 10, 443–456 (2009)

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Authors
  1. Meera Swami
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Swami, M. Non-cooperative transcriptional control. Nat Rev Genet 11, 240 (2010). https://doi.org/10.1038/nrg2768

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