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Small RNAs

A novel class

Nature Reviews Genetics volume 11, page 594 (2010)Cite this article

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Recent profiling studies have identified many new types of small RNA, indicating a greater degree of transcriptome complexity than previously suspected. Now, an unusual class of small RNAs has been discovered — antisense termini-associated short RNAs (aTASRs) — that might be copied from mRNAs.

Kapranov and colleagues used true single-molecule sequencing of first-strand cDNA to profile transcripts in human cells and found a novel class of small RNAs that map to the termini of annotated genes and are on the antisense strand. These aTASRs were present at many genes, and the genes flanked by these novel RNAs were enriched for translation-related functions, which could provide clues about the potential biological roles of aTASRs.

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References

ORIGINAL RESEARCH PAPER

  1. Kapranov, P. et al. New class of gene-termini-associated human RNAs suggests a novel RNA copying mechanism. Nature 466, 642–646 (2010)

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FURTHER READING

  1. Jacquier, A. et al. The complex eukaryotic transcriptome: unexpected pervasive transcription and novel small RNAs. Nature Rev. Genet. 10, 833–844 (2010)

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Authors
  1. Meera Swami
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Swami, M. A novel class. Nat Rev Genet 11, 594 (2010). https://doi.org/10.1038/nrg2852

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  • DOI: https://doi.org/10.1038/nrg2852

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