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Transcriptional activation at the maternal-to-zygotic transition

Nature Reviews Genetics volume 12, page 805 (2011)Cite this article

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The authors investigated control of transcriptional activation during the maternal-to-zygotic transition (MZT) in Drosophila melanogaster by performing chromatin immunoprecipitation followed by sequencing (ChIP–seq) for the transcription factor Zelda. They found pervasive binding of Zelda at genomic regions that are activated in the MZT, and they found that its binding is associated with open chromatin. Their evidence suggests that Zelda is a crucial regulator of MZT and raises the possibility that similar factors could perform this function in other species.

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ORIGINAL RESEARCH PAPER

  1. Harrison, M. M. et al. Zelda binding in the early Drosophila melanogaster embryo marks regions subsequently activated at the maternal-to-zygotic transition. PLoS Genet. 10, e1002266 (2011)

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  1. Hannah Stower
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Stower, H. Transcriptional activation at the maternal-to-zygotic transition. Nat Rev Genet 12, 805 (2011). https://doi.org/10.1038/nrg3120

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