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Gene regulation

Polycomb and non-coding RNA relocate genes

Nature Reviews Genetics volume 13, page 2 (2012)Cite this article

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This study reveals the coordinated action of several modes of transcriptional regulation. The authors found that, in mammals, growth signals alter the methylation of Polycomb 2 protein (PC2), and this leads to the relocation of genes bound by PC2 from repressive Polycomb bodies to transcriptionally active interchromatin granules, or vice versa. They show that this movement is a consequence of methylation altering the binding of PC2 to specific non-coding RNAs that are located in these nuclear compartments.

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ORIGINAL RESEARCH PAPER

  1. Yang, L. et al. ncRNA- and Pc2 methylation-dependent gene relocation between nuclear structures mediates gene activation programs. Cell 147, 773–788 (2011) Article

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  1. Mary Muers
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Muers, M. Polycomb and non-coding RNA relocate genes. Nat Rev Genet 13, 2 (2012). https://doi.org/10.1038/nrg3146

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