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Human epigenetics

Showing your age

Nature Reviews Genetics volume 14, page 6 (2013)Cite this article

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Characterizing the molecular features of ageing is key for understanding the mechanisms of normal and premature ageing, and has applications such as predicting the age of an individual from a forensic sample. A new study has characterized the DNA methylomes of large cohorts of humans, identifying various predictors of age and ageing rates.

These blood-derived signatures were also applicable to various other normal tissues, implying that molecular ageing at the level of DNA methylation is similar across tissue types.

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ORIGINAL RESEARCH PAPER

  1. Hannum, G. et al. Genome-wide methylation profiles reveal quantitative views of human aging rates. Mol. Cell 21 Nov 2012 (doi:10.1016/j.molcel.2012.10.016)

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  1. Darren J. Burgess
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Burgess, D. Showing your age. Nat Rev Genet 14, 6 (2013). https://doi.org/10.1038/nrg3391

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