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Genome organization

Supercoiled roles

Nature Reviews Genetics volume 14, page 239 (2013)Cite this article

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Kouzine et al. and Naughton et al., both using human cell lines, developed techniques for probing supercoiling of DNA using compounds that intercalate and crosslink negatively supercoiled DNA on exposure to ultraviolet light. The crosslinked DNA is then isolated and assayed using arrays to determine its location.

supercoiling has a role in the generation of genome organization features and may also contribute actively to gene regulation

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References

  1. Kouzine, F. et al. Transcription-dependent dynamic supercoiling is a short-range genomic force. Nature Struct. Mol. Biol. 17 Feb 2012 (10.1038/nsmb.2517)

  2. Naughton, C. et al. Transcription forms and remodels supercoiling domains unfolding large-scale chromatin structures. Nature Struct. Mol. Biol 17 Feb 2012 (10.1038/nsmb.2509)

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Authors
  1. Hannah Stower
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Stower, H. Supercoiled roles. Nat Rev Genet 14, 239 (2013). https://doi.org/10.1038/nrg3452

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