Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Research Highlight
  • Published:

Evolution

Proteins partner up in a vigorous relationship

Nature Reviews Genetics volume 14, page 822 (2013)Cite this article

Subjects

Access through your institution
Buy or subscribe

The Saccharomyces sensu stricto yeasts are excellent models in which to study the effect of hybridization — they are a diverse monophyletic group that cross to form stable hybrids which inhabit new ecological niches. From this group of species, the authors crossed either Saccharomyces mikatae or Saccharomyces uvarum with a range of Saccharomyces cerevisiae strains that each carried an affinity-tagged subunit in one of six protein complexes that they had chosen to study. The authors used this tag to purify protein complexes and identified constituent subunits using mass spectrometry.

Four of the six complexes that were studied could form chimeric complexes (that is, complexes containing protein subunits from both parental strains). The authors attributed the lack of formation of interspecies proteins by the other two protein complexes to incompatible changes in protein interfaces or to stoichiometric imbalances.

This is a preview of subscription content, access via your institution

Access options

Access through your institution

Buy this article

  • Purchase on SpringerLink
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Piatkowska, E. M. et al. Chimeric protein complexes in hybrid species generate novel phenotypes. PLoS Genet. http://dx.doi.org/10.1371/journal.pgen.1003836 (2013)

Download references

Authors
  1. Hannah Stower
    View author publications

    Search author on:PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Stower, H. Proteins partner up in a vigorous relationship. Nat Rev Genet 14, 822 (2013). https://doi.org/10.1038/nrg3617

Download citation

  • Published:

  • Issue date:

  • DOI: https://doi.org/10.1038/nrg3617

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing