Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • In Brief
  • Published:

Technology

Mapping small-molecule binding sites

Nature Reviews Genetics volume 15, page 67 (2014)Cite this article

Subjects

Anders and colleagues have developed a new method called Chem–seq to determine the genomic sites where small molecules interact with target proteins or DNA. Similarly to chromatin immunoprecipitation followed by sequencing (ChIP–seq), Chem–seq integrates ligand affinity capture with massively parallel DNA sequencing. Together with other genome-wide analysis techniques such as ChIP–seq, mapping the interaction sites of small-molecule drugs may provide insights into their mechanisms of action and their specificity.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on SpringerLink
  • Instant access to the full article PDF.

USD 39.95

Prices may be subject to local taxes which are calculated during checkout

References

  1. Anders, L. et al. Genome-wide localization of small molecules. Nature Biotech. http://dx.doi.org/10.1038/nbt.2776 (2013)

Download references

Authors
  1. Isabel Lokody
    View author publications

    Search author on:PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lokody, I. Mapping small-molecule binding sites. Nat Rev Genet 15, 67 (2014). https://doi.org/10.1038/nrg3670

Download citation

  • Published:

  • Issue date:

  • DOI: https://doi.org/10.1038/nrg3670

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing