BRD4 and JMJD6 regulate antipause enhancers

Lokody, Isabel

doi:10.1038/nrg3671

In Brief
Published: 16 January 2014

Enhancers

BRD4 and JMJD6 regulate antipause enhancers

Isabel Lokody

Nature Reviews Genetics volume 15, page 67 (2014)Cite this article

1841 Accesses
Metrics details

Subjects

Access through your institution

Buy or subscribe

Pausing and pause release of RNA polymerase II (Pol II) in early transcription elongation are key regulatory events for several genes and have important roles in development, homeostasis and disease. Liu and colleagues now show that distal enhancers have a role in regulating pause release. They demonstrate that BRD4 and JMJD6 recruitment to these 'antipause enhancers' in cultured human cells causes removal of a repressive chromatin mark at these enhancers, which allows them to loop to the promoter. This ultimately results in pause release of Pol II and subsequent activation of a large subset of genes.

This is a preview of subscription content, access via your institution

Access options

Access through your institution

Buy this article

Purchase on SpringerLink
Instant access to full article PDF

Buy now

Prices may be subject to local taxes which are calculated during checkout

References

Liu, W. et al. Brd4 and JMJD6-associated anti-pause enhancers in regulation of transcriptional pause release. Cell 155, 1581–1595 (2013)
Article CAS Google Scholar

Download references

Authors