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Molecular genetics

Insights into nucleolar formation and propagation

Nature Reviews Genetics volume 15, page 147 (2014)Cite this article

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The nucleolus is a cellular compartment, with roles in ribosome biogenesis and cellular proliferation, which breaks down during mitosis and reforms around uncharacterized chromosomal features called nucleolar organizer regions (NORs). Grob and colleagues used a synthetic biology approach to investigate nucleolar propagation through mitosis in a human cell line. They identified the protein UBF1 as key for regulating NOR competency and they characterized the DNA sequence requirements for a functional synthetic nucleolus. In addition, they showed that NORs occupy distinct territories in nucleoli and that nucleolar biogenesis is a conserved process.

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References

  1. Grob, A. et al. Construction of synthetic nucleoli in human cells reveals how a major functional nuclear domain is formed and propagated through cell division. Genes Dev. http://dx.doi.org/10.1101/gad.234591.113 (2014)

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  1. Isabel Lokody
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Lokody, I. Insights into nucleolar formation and propagation. Nat Rev Genet 15, 147 (2014). https://doi.org/10.1038/nrg3695

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